Research Information - Nasha mukti

Research Work Done

To assess the detoxification efficacy, these medicines were subjected to animal trials and thoroughly tested upon animals of various species for different intoxicants such as :

Alcohol:

At first, these medicines were tested for addiction of alcohol in monkeys. To begin with, experimental neurosis was developed in monkeys by subjecting them to neurotogenic trauma.They were served food; and a rubber snake was concealed in their food. While eating, they sighted the rubber snake in their food.They got agitated and refused to eat. By virtue of repetition of this process, neurosis developed in them. Then, they were given 1.5 ml/kg (body weight) alcohol. This dose of alcohol disintegrated the neurotic complex. Neurotic monkeys, when mildly intoxicated, resumed eating. After experiencing relief from neurotic tension, they preferred taking some alcohol before meals; otherwise, they were unable to take food. Hence, addiction to alcohol developed in them.

These monkeys were divided into two groups. One group was given Detoxin and the other group was given Placebo with following results:

Group treated with	No. of monkeys treated	No. of monkeys resumed eating without alcohol	No. of monkeys resumed eating but less without alcohol	No. of monkeys did not resume eating
Detoxin	10	8	1	1
Placebo	10	Nil	1	9

Morphine: Acute dependence

This experiment was conducted upon Albino mice. Samples of 60 Albino mice were taken and were given Morphine HCL 20 mg/kg (body weight). About 4 hours later these mice were divided into two groups. One group was given Detoxin and the other one Placebo. After 5 minutes. both groups were given Nalaxone 5 mg/kg (body weight). Following results observed:

Group treated with	Total no. of mice	no withdrawals found in	Rearing occurred	Jumping, urination, defaecation occurred in
Detoxin	30	22	7	1
Placebo	30	3	27	27

Barbiturates

For this experiment, samples of 20 cats were taken. They were given Sodium Barbital 95 mg/kg (body weight) two times daily and this dose was increased gradually, until the dose level of Sodium Barbital reached to 200 mg/kg in 180 days. Then, these cats were divided into two groups and were deprived of Sodium Barbital. Thereafter, one group was given Detoxin and Placebo was given to the other group. Following results observed:

Group treated with	No. of cats	Strong seizures occurred in	Mild seizures occurred in	seizure occurred in
Detoxin	10	–	2	8
Placebo	10	9	1	–

Clinical Trial

192 cases of addicts of various types were studied. Directly administering Detoxin to the control group was not considered necessary as Placebo effect gets nullified while testing the potencies. Moreover, each potency of Detoxin can not suit to a person. Had there been placebo effects, each potency of Detoxin would suit. This study of 192 cases was conducted for 1 year. The Observations are as follows:

AGE :

Below 20 yrs.	21-30 yrs.	31-40 yrs.	41-50 yrs.	51-60 yrs.	Above 60 yrs.
14	72	57	25	17	7

Educational Status :

Nil	Primary School	Junior High School	High School	Intermediate
39	17	25	32	29

Graduate	Post Graduate	Professionals	Misc.
23	9	13	5

Profession :

Unemployed	Govt. Service	Advocate	Farmer	Driver	Hotel	Business
26	18	4	34	16	2	21

Pvt. Service	Doctor	Student	Technical	Laborer	Misc.
9	5	15	4	4	34

Marital Status :

Unmarried	Married	Widower	Divorcee	Separated
22	91	10	27	42

Addiction :

Alcohol	Cannabis	Opiates	Alcohol, Cannabis	Alcohol, Opiates
69	13	58	15	9

Alcohol, Diazepam, Opiates	Alcohol, Cannabis, Opiates	Opiates, Diazepam	Cannabis, Opiates
3	9	1	15

Relapse :

Alcohol	Cannabis	Opiates	Alcohol, Cannabis	Alcohol, Opiates
32	4	26	3	3

Alcohol, Diazepam, Opiates	Alcohol, Cannabis, Opiates	Opiates, Diazepam	Cannabis, Opiates
1	2	1	6

Relapsed During :

0-3 months	3-6 months	6-9 months	After 9 months
35	21	12	10

Relapsed Due to :

Withdrawal	Craving	Impotency	Family Tension	Company	Drug Peddling
3	4	31	14	9	17

Another separate study was also conducted in which cases of smoking/chewing tobacco were studied; though, some of them used to take occasionally other intoxicants or were addicted to them such as alcohol, cannabis, sedatives, Hypnotics and antidepressent. Details are as follows :

Addiction :

Chewing Tobacco	Smoking	Both
95	531	41

Relapse :

Chewing Tobacco	Smoking	Both
19	117	8

Relapsed During :

1st week	2-4 week	2-3 months	3-6 months	6-9 months	After 9 months
23	36	21	26	23	15

Relapsed Due to :

Did not take medicine properly	Urge	With-drawl	Persuasion by someone	curiosity
19	13	5	8	32

Mental shock	no reason	Loneliness	Desire to hold some- thing between fingers	ignorance of the medical instructions
12	27	4	6	18

When they smoked again, they experienced :

Aversion	Usual taste	Mild taste /tastelessness
63	37	44

The persons who got relapsed, started to take quantity/day :

Reduced	Same	increased
88	43	13